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CLINICAL PIPELINE

Breakthrough Molecules, Breakthrough Care.

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Our comprehensive pipeline spans from natural compounds to novel synthetic entities. Cubed is advancing a dual-track drug pipeline for high-impact psychiatric indications, with a long-term strategy to enter the neurodegenerative disease space.
After establishing a regulatory and commercial foothold in psychiatric indications, Cubed will pursue neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease, and Traumatic Brain Injury (TBI). Initial entry will focus on mood and anxiety symptoms in these populations, where endpoints are validated, before exploring disease-modifying potential. Trials can be repeated for Generalized Anxiety Disorder (GAD), Major Depression & PTSD.

This staged approach mitigates the higher regulatory and trial complexity inherent in neurodegeneration in older patients while leveraging early psychiatric success to build clinical, CMC, and investor credibility.

CB-001

Tigrina

Natural Psilocybin Isolate

    99.66% purity

    Indication: Treatment-Resistant Depression (TRD) & Major Depressive Disorder (MDD)

    Formulation: Full-spectrum, strain-specific isolate

    Targets a U.S. TRD market of ~USD 1 B annually.

CB-002

Ocelot

Hybrid Novel Chemical Entity Library

    Indication: MDD, Anxiety Disorders, Neurodegeneration

    Advantage: Non-hallucinogenic 5-HT2A modulators, first-in-class opportunities

    Platform: Library of 50+ hybrid molecules (tryptamine/phenylethylamine based)

    Status: Early discovery → IND-enabling studies

CB-003

Amur

Full Spectrum Psilocybin Capsule

    Indication: Treatment-Resistant Depression (TRD) & Major Depressive Disorder (MDD)

    Positioned for direct entry into Phase 2a under FDA Botanical Drug Guidance using prior human use data to waive Phase 1.

    A GMP-manufactured oral capsule containing psilocybin and natural secondary alkaloids from Psilocybe species

    Targets a U.S. TRD market of ~USD 1 B annually.

Partners

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